Kyntheum

DESCRIPTION

Kyntheum® is a fully human monoclonal antibody and the only biologic treatment
for moderate to severe plaque psoriasis that selectively targets the IL-17 receptor subunit A2,3
This means that it blocks multiple IL-17 cytokines with an active role in the pathogenesis of plaque psoriasis2,3

COMPLETE CLEARANCE WITH KYNTHEUM®
INDUCTION WAS SUSTAINED
THROUGH TO ONE YEAR.1

kyntheum traitment evolution baseline

Baseline

kyntheum traitment evolution week 4

4 weeks

kyntheum traitment evolution week 12

12 weeks

kyntheum traitment evolution week 24

24 weeks

kyntheum traitment evolution week 52

52 weeks

For illustrative purposes only.  These images provide a look at Kyntheum® impact on one particular patient in the AMAGINE-1 study and do not necessarily represent the results experienced by all patients.

 

WITH KYNTHEUM® (210mg Q2W),
51% OF PATIENTS ACHIEVED PASI 100
AT 1 YEAR COMPARED TO 28%
WITH USTEKINUMAB.1ꝉ

PASI 100 responses during induction and maintenance (pooled AMAGINE-2 and AMAGINE-3).1

KYNTHEUM®. Result comparison

*Psoriasis Area Severity index
** Data are combined from AMAGINE-2 and AMAGINE-3
ꝉ Every two weeks

COMPOSITION

Kyntheum® is delivered in pre-filled syringes each containing 210 mg of brodalumab in 1.5 ml solution.
1 ml of solution contains 140 mg of brodalumab.1

List of excipients:
Proline
Glutamate
Polysorbate 20
Water for injections

PHARMACEUTICAL FORM

Solution for injection.
The solution is clear to slightly opalescent, colourless to slightly yellow and free of particles1.

PHARMACOLOGICAL PROPERTIES

Kyntheum® blocks the biological activity of the proinflammatory cytokines IL-17A, IL-17F, heterodimer IL-17A/F and IL-17E,
and inhibits inflammation and the clinical symptoms associated with psoriasis1.

PHARMACEUTICAL DATA

Special Precautions for Storage

Store in the refrigerator (2° to 8° C).
Do not freeze.
Keep the pre-filled syringe in the outer box to protect it from light1.

Kyntheum® may be stored at room temperature (up to 25°C) once, in the outer carton, for a maximum single period of 14 days.
Once Kyntheum® has been removed from the refrigerator and has reached room temperature (up to 25°C)
it must either be used within 14 days or discarded1.

Access the summary of product characteristics for Kyntheum® – UK
Access the summary of product characteristics for Kyntheum® – Ireland