Supersaturation explained quickly

The clinical relevance of supersaturation is unknown

What makes Enstilar® foam spray different versus Dovobet® (calcipotriol / betamethasone dipropionate) ointment?

Enstilar® shows improved bioavailability of active ingredients vs Dovobet® ointment in an animal model

When pressurised in a can, the propellants of Enstilar® act as a solvent for the active ingredients, calcipotriol and betamethasone dipropionate1

Once Enstilar® is sprayed on the skin, the propellants evaporate to leave fully dissolved, non-crystalline active ingredients available for skin penetration.This is known as supersaturation1

Foam after application

Enstilar® foam spray

Laboratory tests show that the active ingredients of Enstilar® remained in this supersaturated state for 18 to 26 hours after spraying.2

Ointment after application

Dovobet® ointment

After Dovobet® ointment application, crystals of active ingredient were detected.1,2 Crystallisation decreases penetration of active ingredients.2

For illustrative purposes only

An in vitro human skin explant biomarker study showed numerically higher (p=ns) bioavailability of the active ingredients after Enstilar® application vs Dovobet® ointment.2

The clinical relevance of supersaturation is unknown

Patient experience with Enstilar®

In a 4-week prospective, observational, non-interventional efficacy and tolerability study of 391* adult patients with plaque psoriasis under daily practice conditions, at first use, Enstilar® was assessed as:3


“Very/quite cooling


“Very/quite skin satisfying


“Very/quite itch relieving


“Very/quite simple to apply


94.8% of patients were “very satisfied” or “satisfied” with the tolerability of Enstilar® in the final assessment3