Supersaturation explained quickly

The clinical relevance of supersaturation is unknown

What makes Enstilar® foam spray different versus Dovobet® (calcipotriol / betamethasone dipropionate) ointment?

Enstilar® shows improved bioavailability of active ingredients vs Dovobet® ointment in an animal model

When pressurised in a can, the propellants of Enstilar® act as a solvent for the active ingredients, calcipotriol and betamethasone dipropionate1

Once Enstilar® is sprayed on the skin, the propellants evaporate to leave fully dissolved, non-crystalline active ingredients available for skin penetration.This is known as supersaturation1

Foam after application

Enstilar® foam spray

Laboratory tests show that the active ingredients of Enstilar® remained in this supersaturated state for 18 to 26 hours after spraying.2