Supersaturation explained quickly
The clinical relevance of supersaturation is unknown
What makes Enstilar® foam spray different versus Dovobet® (calcipotriol / betamethasone dipropionate) ointment?
Enstilar® shows improved bioavailability of active ingredients vs Dovobet® ointment in an animal model
When pressurised in a can, the propellants of Enstilar® act as a solvent for the active ingredients, calcipotriol and betamethasone dipropionate1
Once Enstilar® is sprayed on the skin, the propellants evaporate to leave fully dissolved, non-crystalline active ingredients available for skin penetration.1 This is known as supersaturation1
Enstilar® foam spray
Laboratory tests show that the active ingredients of Enstilar® remained in this supersaturated state for 18 to 26 hours after spraying.2
Dovobet® ointment
After Dovobet® ointment application, crystals of active ingredient were detected.1,2 Crystallisation decreases penetration of active ingredients.2
For illustrative purposes only
An in vitro human skin explant biomarker study showed numerically higher (p=ns) bioavailability of the active ingredients after Enstilar® application vs Dovobet® ointment.2
The clinical relevance of supersaturation is unknown
Patient experience with Enstilar®
In a 4-week prospective, observational, non-interventional efficacy and tolerability study of 391* adult patients with plaque psoriasis under daily practice conditions, at first use, Enstilar® was assessed as:3
“Very/quite cooling”
“Very/quite skin satisfying”
“Very/quite itch relieving”
“Very/quite simple to apply”
